Get the message out!

Inside Out Signaling : Moving the AT 1 Receptor in To Get the Message Out Running title :

Inside-Out Signaling: Moving the AT1 Receptor in to Get the Message Out.

W ith cardiovascular disease remaining a major cause of morbidity and mortality despite recent therapeutic advances, the molecular basis of heart failure continues to be an active field of investigation. In particular, the renin-angio-tensin system, which plays a major role in blood pressure control and cardiac hypertrophy, has been the subject of countless studies. The renin-angiotensin system...

Get the fat out!

Obesity is associated with increased risk of a number of cancers in humans, but the mechanism(s) responsible for these associations have not been established. It is estimated that 68% of adults are overweight or obese and that obesity may be causative in 4% to 7% of cancers in the United States. Several hypotheses have been put forward to explain the association between obesity and cancer inclu...

Get the message out: cyclic-Di-GMP regulates multiple levels of flagellum-based motility.

Flagella are complex organelles whose synthesis depends upon approximately 50 gene products. Not surprisingly, multiple mechanisms control and direct flagellar biogenesis (reviewed in references 1, 15, and 55). Perhaps best understood is the control exerted at the level of transcription: hierarchies exist, such that the flagellar structural proteins are synthesized only under proper conditions ...

Let's get the lead out.

Approximately 9,000 homes in Kenosha have a lead water service line that delivers fresh municipal water from the Kenosha Water Utility’s cast iron or plastic water mains located in public streets and rights of way, into individual homes that is used for drinking, bathing and cleaning. Th ese lead services lines that connect the fresh water mains to more than 9,000 families were installed prior ...